PT  - JOURNAL ARTICLE
AU  - NEUBERGER, MANUEL
AU  - SKLADNY, JANINA
AU  - GOLY, NORA
AU  - WESSELS, FREDERIK
AU  - WEIß, CHRISTEL
AU  - EGEN, LUISA
AU  - ERBEN, PHILIPP
AU  - GROß-WEEGE, MATTHIAS
AU  - GRÜNE, BRITTA
AU  - HARTUNG, FRIEDRICH
AU  - HERRMANN, JONAS
AU  - HONECK, PATRICK
AU  - JARCZYK, JONAS
AU  - KOWALEWSKI, KARL-FRIEDRICH
AU  - MÜHLBAUER, JULIA
AU  - NITSCHKE, KATJA
AU  - NIENTIEDT, MALIN
AU  - WALACH, MARGARETE THERESA
AU  - WALDBILLIG, FRANK
AU  - WESTHOFF, NIKLAS
AU  - VON HARDENBERG, JOST
AU  - KRIEGMAIR, MAXIMILIAN
AU  - WORST, THOMAS S.
AU  - NUHN, PHILIPP
TI  - Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy
AID  - 10.21873/anticanres.15668
DP  - 2022 Apr 01
TA  - Anticancer Research
PG  - 1911--1918
VI  - 42
IP  - 4
4099  - http://ar.iiarjournals.org/content/42/4/1911.short
4100  - http://ar.iiarjournals.org/content/42/4/1911.full
SO  - Anticancer Res2022 Apr 01; 42
AB  - Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine.