TY - JOUR T1 - Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy JF - Anticancer Research JO - Anticancer Res SP - 1911 LP - 1918 DO - 10.21873/anticanres.15668 VL - 42 IS - 4 AU - MANUEL NEUBERGER AU - JANINA SKLADNY AU - NORA GOLY AU - FREDERIK WESSELS AU - CHRISTEL WEIß AU - LUISA EGEN AU - PHILIPP ERBEN AU - MATTHIAS GROß-WEEGE AU - BRITTA GRÜNE AU - FRIEDRICH HARTUNG AU - JONAS HERRMANN AU - PATRICK HONECK AU - JONAS JARCZYK AU - KARL-FRIEDRICH KOWALEWSKI AU - JULIA MÜHLBAUER AU - KATJA NITSCHKE AU - MALIN NIENTIEDT AU - MARGARETE THERESA WALACH AU - FRANK WALDBILLIG AU - NIKLAS WESTHOFF AU - JOST VON HARDENBERG AU - MAXIMILIAN KRIEGMAIR AU - THOMAS S. WORST AU - PHILIPP NUHN Y1 - 2022/04/01 UR - http://ar.iiarjournals.org/content/42/4/1911.abstract N2 - Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine. ER -