%0 Journal Article %A FRANCESCO INSERRA %A FABIO BARONE %A PAOLO PALMISCIANO %A GIANLUCA SCALIA %A VALERIO DA ROS %A AHMED ABDELSALAM %A ANTONIO CREA %A MARIA GABRIELLA SABINI %A SANTINO O. TOMASI %A GIANLUCA FERINI %A ROSARIO MAUGERI %A LIDIA STRIGARI %A GIUSEPPE EMMANUELE UMANA %T Hypofractionated Gamma Knife Radiosurgery: Institutional Experience on Benign and Malignant Intracranial Tumors %D 2022 %R 10.21873/anticanres.15661 %J Anticancer Research %P 1851-1858 %V 42 %N 4 %X Background/Aim: We investigated the treatment outcomes and complications associated with hypofractionated GKRS for the treatment of benign and malignant intracranial tumors. Patients and Methods: Patients with intracranial tumors not candidate or refusing surgery were evaluated to assess eligibility to undergo hypofractionated Gamma Knife radiosurgery (GKRS). Targeted volumes were calculated using the GammaPlan® workstation, and GKRS protocols were delivered with 3 or 5 daily fractions and a maximal total dose of 25 Gy. The thermoplastic mask was used to immobilize the patient’s head without pin-based fixation frames. Results: A total of 41 patients, affected with 6 different histologies, were treated and followed-up for a median of 12 months (range=4-24 months). Meningiomas were the most common tumors (33, 80.5%), followed by brain metastases (4, 9.7%). At last follow-up, 33 patients (80.5%) had stable disease, 8 tumor regression (19.5%), and 0 tumor progression. No acute radiation toxicity was observed. Death was reported in 3 patients (7.3%) due to malignant tumor progression. Conclusion: Our hypofractionated GKRS protocol proved to be effective and safe in the treatment of patients with benign and malignant intracranial tumors. Local tumor control was achieved in all patients, with 8 patients showing tumor regression and no cases of acute radiation toxicity. %U https://ar.iiarjournals.org/content/anticanres/42/4/1851.full.pdf