TY - JOUR T1 - Hypofractionated Gamma Knife Radiosurgery: Institutional Experience on Benign and Malignant Intracranial Tumors JF - Anticancer Research JO - Anticancer Res SP - 1851 LP - 1858 DO - 10.21873/anticanres.15661 VL - 42 IS - 4 AU - FRANCESCO INSERRA AU - FABIO BARONE AU - PAOLO PALMISCIANO AU - GIANLUCA SCALIA AU - VALERIO DA ROS AU - AHMED ABDELSALAM AU - ANTONIO CREA AU - MARIA GABRIELLA SABINI AU - SANTINO O. TOMASI AU - GIANLUCA FERINI AU - ROSARIO MAUGERI AU - LIDIA STRIGARI AU - GIUSEPPE EMMANUELE UMANA Y1 - 2022/04/01 UR - http://ar.iiarjournals.org/content/42/4/1851.abstract N2 - Background/Aim: We investigated the treatment outcomes and complications associated with hypofractionated GKRS for the treatment of benign and malignant intracranial tumors. Patients and Methods: Patients with intracranial tumors not candidate or refusing surgery were evaluated to assess eligibility to undergo hypofractionated Gamma Knife radiosurgery (GKRS). Targeted volumes were calculated using the GammaPlan® workstation, and GKRS protocols were delivered with 3 or 5 daily fractions and a maximal total dose of 25 Gy. The thermoplastic mask was used to immobilize the patient’s head without pin-based fixation frames. Results: A total of 41 patients, affected with 6 different histologies, were treated and followed-up for a median of 12 months (range=4-24 months). Meningiomas were the most common tumors (33, 80.5%), followed by brain metastases (4, 9.7%). At last follow-up, 33 patients (80.5%) had stable disease, 8 tumor regression (19.5%), and 0 tumor progression. No acute radiation toxicity was observed. Death was reported in 3 patients (7.3%) due to malignant tumor progression. Conclusion: Our hypofractionated GKRS protocol proved to be effective and safe in the treatment of patients with benign and malignant intracranial tumors. Local tumor control was achieved in all patients, with 8 patients showing tumor regression and no cases of acute radiation toxicity. ER -