TY - JOUR T1 - Feasibility of 21-day Continuous Infusion of Epirubicin in Hormone-refractory Prostate Cancer Patients JF - Anticancer Research JO - Anticancer Res SP - 4475 LP - 4479 VL - 25 IS - 6C AU - ALFREDO BERRUTI AU - ALESSANDRA MOSCA AU - RAFFAELLA BITOSSI AU - GABRIELLA GORZEGNO AU - STEFANO GUERCIO AU - MASSIMILIANO POGGIO AU - MARCO TAMPELLINI AU - FRANCESCO PORPIGLIA AU - OLIVIERO OSTELLINO AU - ROBERTO MARIO SCARPA AU - LUIGI DOGLIOTTI Y1 - 2005/11/01 UR - http://ar.iiarjournals.org/content/25/6C/4475.abstract N2 - Background: Epirubicin (EPX) has been found to be active in hormone-refractory prostate cancer (HRPC) patients. Prolonged EPX infusion has never been investigated in this patient subset. Patients and Methods: A feasibility study was conducted in which EPX was administered in 21-day continuous infusion to 15 patients with HRPC. The EPX dose was 5 mg/m2/daily for 21 consecutive days (one course). One week was allowed before starting the next course. Results: The patients received 1 to 6 courses (median 3). As a whole, the treatment was well tolerated. Nine patients did not develop any toxicity, while WHO grade 3 and 4 toxicities were recorded in 4 patients. Alopecia (WHO grade 1-2) was presented in 4 cases. Five patients attained >50% decrease in serum prostate-specific antigen (PSA). Conclusion: Prolonged EPX infusion is feasible and potentially active in the treatment of HRPC patients. Our data suggest caution in administering this treatment in patients bearing rheumatologic disease. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -