RT Journal Article SR Electronic T1 Clinical Outcomes of Radiotherapy in Elderly and Younger Patients With T4 Esophageal Cancer: A Retrospective Single-center Analysis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2095 OP 2104 DO 10.21873/anticanres.15691 VO 42 IS 4 A1 YOSUKE TAKAKUSAGI A1 KIO KANO A1 SATOSHI SHIMA A1 KEISUKE TSUCHIDA A1 NOBUTAKA MIZOGUCHI A1 HIROYUKI KATOH A1 TADASHI KAMADA A1 RISA TANIUCHI A1 MISAKI IINO A1 TOMOMI AOSHIKA A1 SATOSHI SAITO A1 DAISAKU YOSHIDA YR 2022 UL http://ar.iiarjournals.org/content/42/4/2095.abstract AB Background/Aim: The standard of treatment for esophageal cancer with adjacent organ invasion (T4) has not been established. We retrospectively analyzed the clinical outcomes of radiotherapy (RT) in elderly and younger patients with T4 esophageal cancer. Patients and Methods: Sixty-nine patients with T4 esophageal cancer who underwent RT at the Kanagawa Cancer Center between January 2014 and November 2020 were included in this study. Patients aged ≥70 years were defined as the elderly group and those aged <70 years were defined as the younger group. The total dose of RT was set at 60 Gy in 30 fractions. Chemotherapy combined with 5-fluorouracil and cisplatin was administered concurrently with RT in general. The overall survival (OS) rate was estimated using the Kaplan–Meier method. Adverse events were assessed using CTCAE v4.0. Results: The median survival time (MST) of the elderly group (n=35) was 21.5 months, and the OS rates at 1, 3, and 5 years were 63.7%, 31.3%, and 15.6%, respectively. The MST of the younger group (n=34) was 12.5 months, and the OS rates at 1, 3, and 5 years were 52.2%, 29.4%, and 29.4%, respectively. No significant difference in OS was observed between the two groups (p=0.767). Toxicities were not significantly different between the two groups except for thrombocytopenia and esophageal fistula (p=0.012 and p=0.022, respectively). Conclusion: The clinical outcomes of RT for T4 esophageal cancer in elderly patients were generally similar to those in the younger group.