RT Journal Article
SR Electronic
T1 Carbon Ion Radiotherapy in the Management of the Tumors of the Peripheral Nervous System
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 909
OP 913
DO 10.21873/anticanres.13193
VO 39
IS 2
A1 VITOLO, VIVIANA
A1 FIORE, MARIA ROSARIA
A1 BARCELLINI, AMELIA
A1 VISCHIONI, BARBARA
A1 IANNALFI, ALBERTO
A1 FACOETTI, ANGELICA
A1 FOSSATI, PIERO
A1 BONORA, MARIA
A1 RONCHI, SARA
A1 D'IPPOLITO, EMMA
A1 PETRUCCI, RACHELE
A1 VISELNER, GISELA
A1 CIOCCA, MARIO
A1 PREDA, LORENZO
A1 VALVO, FRANCESCA
A1 ORECCHIA, ROBERTO
YR 2019
UL http://ar.iiarjournals.org/content/39/2/909.abstract
AB Background/Aim: Malignant peripheral nerve sheaths tumors (MPNST) are rare, highly aggressive and radioresistant tumors of soft tissue. Carbon ion radiotherapy (CIRT) seems to be an attractive treatment option when surgery is not possible or refused by the patient. The aim of this study was to report our preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs. Patients and Methods: Our study retrospectively analyzed 13 patients (median age=54 years; range=23-72 years) with MPNST treated with CIRT for a median total dose of 73.6 Gy (relative biological effectiveness) (range=70.4-76.8 Gy) between 2013 and 2016. Results: Six local progressions were recorded, with a median local progression-free survival of 23.2 months (range=2.2-45.4 months). Acute toxicities were mild. Late toxicity of grade 2 or more was noted in two patients. Conclusion: CIRT yielded good local control with a low rate of acute and late toxicities.