PT  - JOURNAL ARTICLE
AU  - NITHIKOON AKSORN
AU  - PITHI CHANVORACHOTE
TI  - Integrin as a Molecular Target for Anti-cancer Approaches in Lung Cancer
AID  - 10.21873/anticanres.13146
DP  - 2019 Feb 01
TA  - Anticancer Research
PG  - 541--548
VI  - 39
IP  - 2
4099  - http://ar.iiarjournals.org/content/39/2/541.short
4100  - http://ar.iiarjournals.org/content/39/2/541.full
SO  - Anticancer Res2019 Feb 01; 39
AB  - Integrins are cell-matrix adhesion molecules providing both mechanical engagement of cell to extracellular matrix, and generation of cellular signals that are implicated in cancer malignancies. The concept that integrins play important roles in cell survival, proliferation, motility, differentiation, and ensuring appropriate cell localization, leads to the hypothesis that inhibition of certain integrins would benefit cancer therapy. In lung cancer, integrins αv, α5, β1, β3, and β5 have been shown to augment survival and metastatic potential of cancer cells. This review presents data suggesting integrins as molecular targets for anti-cancer approaches, and the mechanisms through which integrins confer resistance of lung cancer to chemotherapeutics and metastasis. The better understanding of these key molecules may benefit the discovery of anti-cancer drugs and strategies.