TY - JOUR T1 - The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 1589 LP - 1598 DO - 10.21873/anticanres.15633 VL - 42 IS - 3 AU - TAKEHIRO OTOSHI AU - TATSUYA NAGANO AU - JONGUK PARK AU - KOJI HOSOMI AU - TOMOYA YAMASHITA AU - MOTOKO TACHIHARA AU - TOKIKO TABATA AU - REINA SEKIYA AU - YUGO TANAKA AU - KAZUYUKI KOBAYASHI AU - KENJI MIZUGUCHI AU - TOMOO ITOH AU - YOSHIMASA MANIWA AU - JUN KUNISAWA AU - YOSHIHIRO NISHIMURA Y1 - 2022/03/01 UR - http://ar.iiarjournals.org/content/42/3/1589.abstract N2 - Background/Aim: The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of several diseases, including cancer. In this study, we examined the relationship between the gut microbiome and lung cancer progression. Patients and Methods: Female never-smokers diagnosed with lung adenocarcinoma were consecutively enrolled between May 2018 and August 2019, and fecal samples were collected. Principal coordinate analyses were performed using Bray-Curtis distance matrices to investigate the effects of clinical variables (age, body mass index, Tumor-Node-Metastasis stage, T category, N category, M category, primary tumor size, performance status, and EGFR mutation status) on the gut microbial community. Results: A total of 37 patients were enrolled. T category and primary tumor size were significantly correlated with the gut microbial community (p=0.018 and 0.041, respectively). Conclusion: This study identified the gut microbiome as a promising biomarker of lung cancer progression. ER -