RT Journal Article SR Electronic T1 Laboratory Parameters Associated With Inflammation Do Not Affect PD-L1 Expression in Non-small Cell Lung Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1563 OP 1569 DO 10.21873/anticanres.15630 VO 42 IS 3 A1 MARTIN SVATON A1 MARIE DROSSLEROVA A1 ONDREJ FISCHER A1 MILOSLAV MAREL A1 MICHAL HRNCIARIK A1 ONDREJ VENCLICEK A1 PETR ZUNA A1 MICHAL SVOBODA A1 JIRI BLAZEK A1 MONIKA BRATOVA A1 ANDREA MULLEROVA A1 BOHUSLAVA VANKOVA A1 DANIEL KREJCI YR 2022 UL http://ar.iiarjournals.org/content/42/3/1563.abstract AB Background/Aim: Due to some interconnectedness at the molecular level, this study assessed the possible influence of laboratory parameters associated with systemic inflammatory environment on programmed death-ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC). Patients and Methods: We assessed effects of c-reactive protein (CRP), albumin, haemoglobin, neutrophil, and lymphocyte levels on PD-L1 expression in NSCLC. Patient data were obtained retrospectively from LUCAS, the Czech registry of patients with lung carcinomas. Correlations of two continuous parameters (PD-L1 expression and laboratory parameters) were analysed by correlation coefficient. Differences in continuous parameters between two or more groups were tested by Mann–Whitney or Kruskal–Wallis tests. Independence of two categorical parameters was tested by chi-square test. Results: We demonstrated no influence of the investigated laboratory parameters on PD-L1 expression in NSCLC, either in continuous or categorical division of variables. Conclusion: Inflammatory laboratory parameters at time of NSCLC diagnosis are unlikely to affect the determination of PD-L1 expression.