PT  - JOURNAL ARTICLE
AU  - MARTIN SVATON
AU  - MARIE DROSSLEROVA
AU  - ONDREJ FISCHER
AU  - MILOSLAV MAREL
AU  - MICHAL HRNCIARIK
AU  - ONDREJ VENCLICEK
AU  - PETR ZUNA
AU  - MICHAL SVOBODA
AU  - JIRI BLAZEK
AU  - MONIKA BRATOVA
AU  - ANDREA MULLEROVA
AU  - BOHUSLAVA VANKOVA
AU  - DANIEL KREJCI
TI  - Laboratory Parameters Associated With Inflammation Do Not Affect PD-L1 Expression in Non-small Cell Lung Cancer
AID  - 10.21873/anticanres.15630
DP  - 2022 Mar 01
TA  - Anticancer Research
PG  - 1563--1569
VI  - 42
IP  - 3
4099  - http://ar.iiarjournals.org/content/42/3/1563.short
4100  - http://ar.iiarjournals.org/content/42/3/1563.full
SO  - Anticancer Res2022 Mar 01; 42
AB  - Background/Aim: Due to some interconnectedness at the molecular level, this study assessed the possible influence of laboratory parameters associated with systemic inflammatory environment on programmed death-ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC). Patients and Methods: We assessed effects of c-reactive protein (CRP), albumin, haemoglobin, neutrophil, and lymphocyte levels on PD-L1 expression in NSCLC. Patient data were obtained retrospectively from LUCAS, the Czech registry of patients with lung carcinomas. Correlations of two continuous parameters (PD-L1 expression and laboratory parameters) were analysed by correlation coefficient. Differences in continuous parameters between two or more groups were tested by Mann–Whitney or Kruskal–Wallis tests. Independence of two categorical parameters was tested by chi-square test. Results: We demonstrated no influence of the investigated laboratory parameters on PD-L1 expression in NSCLC, either in continuous or categorical division of variables. Conclusion: Inflammatory laboratory parameters at time of NSCLC diagnosis are unlikely to affect the determination of PD-L1 expression.