PT - JOURNAL ARTICLE AU - OTHMAN BIN ALAMER AU - PAOLO PALMISCIANO AU - SCOTT E. ROWE AU - ADITYA DUTTA GUPTA AU - MARYAM HAIDER AU - MOHAMMED ALDUHAYMI AU - AARON A. COHEN-GADOL AU - KENNY YU AU - TAREK Y. EL-AHMADIEH AU - ALI S. HAIDER TI - Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes AID - 10.21873/anticanres.15585 DP - 2022 Mar 01 TA - Anticancer Research PG - 1189--1198 VI - 42 IP - 3 4099 - http://ar.iiarjournals.org/content/42/3/1189.short 4100 - http://ar.iiarjournals.org/content/42/3/1189.full SO - Anticancer Res2022 Mar 01; 42 AB - Background/Aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. Materials and Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Results: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. Conclusion: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.