%0 Journal Article %A OTHMAN BIN ALAMER %A PAOLO PALMISCIANO %A SCOTT E. ROWE %A ADITYA DUTTA GUPTA %A MARYAM HAIDER %A MOHAMMED ALDUHAYMI %A AARON A. COHEN-GADOL %A KENNY YU %A TAREK Y. EL-AHMADIEH %A ALI S. HAIDER %T Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes %D 2022 %R 10.21873/anticanres.15585 %J Anticancer Research %P 1189-1198 %V 42 %N 3 %X Background/Aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. Materials and Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Results: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. Conclusion: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV. %U https://ar.iiarjournals.org/content/anticanres/42/3/1189.full.pdf