@article {ALAMER1189, author = {OTHMAN BIN ALAMER and PAOLO PALMISCIANO and SCOTT E. ROWE and ADITYA DUTTA GUPTA and MARYAM HAIDER and MOHAMMED ALDUHAYMI and AARON A. COHEN-GADOL and KENNY YU and TAREK Y. EL-AHMADIEH and ALI S. HAIDER}, title = {Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes}, volume = {42}, number = {3}, pages = {1189--1198}, year = {2022}, doi = {10.21873/anticanres.15585}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. Materials and Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Results: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3\%). Fifty patients (61.7\%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0\%) or endoscopic third ventriculostomy (ETV) (24.0\%). Patients who underwent VPS had significant survival benefits compared to ETV (p\<0.05). All patients in our review underwent surgery, and gross-total resection (>=98\%) was achieved in 34.6\%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3\%). Chemotherapy was administered in 32.1\% of cases, and radiotherapy in 40.7\%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60\%. Conclusion: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/42/3/1189}, eprint = {https://ar.iiarjournals.org/content/42/3/1189.full.pdf}, journal = {Anticancer Research} }