PT  - JOURNAL ARTICLE
AU  - SATOSHI SUZUKI
AU  - NAOKI URAKAWA
AU  - HIROSHI HASEGAWA
AU  - SHINGO KANAJI
AU  - KIMIHIRO YAMASHITA
AU  - TAKERU MATSUDA
AU  - TARO OSHIKIRI
AU  - YOSHIHIRO KAKEJI
TI  - Prognostic Predictors After Surgical Intervention for Stage IV Gastric Cancer
AID  - 10.21873/anticanres.15627
DP  - 2022 Mar 01
TA  - Anticancer Research
PG  - 1541--1546
VI  - 42
IP  - 3
4099  - http://ar.iiarjournals.org/content/42/3/1541.short
4100  - http://ar.iiarjournals.org/content/42/3/1541.full
SO  - Anticancer Res2022 Mar 01; 42
AB  - Background/Aim: This study aimed to examine the efficacy of surgical intervention after chemotherapy for stage IV gastric cancer and the predictors of survival after surgical intervention. Patients and Methods: Forty-three gastric cancer patients who had only one type of incurable factor (e.g., para-aortic lymph node metastasis) and had undergone initial chemotherapy, underwent chemotherapy alone (CX group; n=25), palliative gastrectomy (PS group; n=8), and conversion surgery (CS group; n=10). Their therapeutic outcomes were compared. Results: The CS group had significantly higher 2-year overall survival rates (80%) than the CX group (25%), whose prognosis was similar to that of the PS group (23%; p<0.001). Pathological complete response of para-aortic lymph node or peritoneal metastases was an independent predictor of survival after surgery, as was >6 months of chemotherapy. Conclusion: CS may improve the prognosis of patients with stage IV gastric cancer in whom chemotherapy can achieve pathological disappearance of the metastatic lesions.