PT  - JOURNAL ARTICLE
AU  - ABDELHALEEM, MOHAMED
AU  - SUN, TIE-HUA
AU  - HO, MICHAEL
TI  - <em>DHX32</em> Expression Suggests a Role in Lymphocyte Differentiation
DP  - 2005 Jul 01
TA  - Anticancer Research
PG  - 2645--2648
VI  - 25
IP  - 4
4099  - http://ar.iiarjournals.org/content/25/4/2645.short
4100  - http://ar.iiarjournals.org/content/25/4/2645.full
SO  - Anticancer Res2005 Jul 01; 25
AB  - RNA helicases constitute a large group of enzymes involved in all aspects of RNA metabolism. Several RNA helicases are dysregulated in cancer, whereas several others are involved in differentiation. DHX32 has previously been identified as a novel RNA helicase with a unique structure and expression pattern. DHX32 message was down-regulated in acute lymphoblastic leukemia cell lines and patient samples. In this report, anti-DHX32 was used to study its expression in thymus. Immunohistochemistry and flow cytometry showed positive correlation of DHX32 expression with thymocyte maturation. These results suggest that DHX32 might play a role in normal lymphocyte differentiation. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved