PT  - JOURNAL ARTICLE
AU  - IMAMURA, YASUHIRO
AU  - HIBI, KENJI
AU  - KOIKE, MASAHIKO
AU  - FUJIWARA, MICHITAKA
AU  - KODERA, YASUHIRO
AU  - ITO, KATSUKI
AU  - NAKAO, AKIMASA
TI  - <em>RUNX3</em> Promoter Region is Specifically Methylated in Poorly-differentiated Colorectal Cancer
DP  - 2005 Jul 01
TA  - Anticancer Research
PG  - 2627--2630
VI  - 25
IP  - 4
4099  - http://ar.iiarjournals.org/content/25/4/2627.short
4100  - http://ar.iiarjournals.org/content/25/4/2627.full
SO  - Anticancer Res2005 Jul 01; 25
AB  - Background, Materials and Methods: It has recently become clear that RUNX3 expression is frequently silenced by aberrant methylation in gastric cancers. In this study, we investigated the methylation status of the RUNX3 gene in 92 resected primary colorectal cancers using methylation-specific PCR (MSP) and correlated the results with the clinicopathological features of affected patients. Results: Aberrant promoter methylation of the RUNX3 gene was detected in 31 out of 92 (34%) colorectal cancers. A significant difference in histology (p=0.028) was also found on comparing the RUNX3 methylation of poorly-differentiated colorectal cancers to that of other differentiated ones. Conclusion: RUNX3 aberrant methylation might play an important role in colorectal cancers, especially in poorly-differentiated colorectal cancers. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved