RT Journal Article
SR Electronic
T1 Intracellular and Extracellular <em>myo</em>-Inositol Hexakisphosphate (InsP<sub>6</sub>), from Rats to Humans
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2593
OP 2597
VO 25
IS 3C
A1 GRASES, F.
A1 COSTA-BAUZA, A.
A1 PRIETO, R.M.
YR 2005
UL http://ar.iiarjournals.org/content/25/3C/2593.abstract
AB The presence of myo-inositol hexakisphosphate (InsP6) in biological fluids (blood, urine, saliva, interstitial fluid) of mammalians has been clearly demonstrated. The existence of intracellular InsP6 in mammalian cells has also been established. Further, significant extracellular and intracellular functions of this molecule have been found. The relationship between InsP6 ingestion and the InsP6 distribution in various tissues of mammalians is discussed. It was found that the majority of the extracellular InsP6 found in organs, tissues and biological fluids of mammalians has a dietary origin and is not a consequence of endogenous synthesis, whereas the intracellular InsP6 probably originates in the cell. Little absorption of dietary InsP6 takes place during intestinal transit and depletion of extracellular InsP6 occurs at high rates when InsP6-poor diets are consumed. From these results, it can be deduced that health benefits linked to extracellular InsP6 must be related to dietary InsP6.