PT  - JOURNAL ARTICLE
AU  - HO, CHIEN-YI
AU  - HU, DAI-WEI
AU  - CHEN, BO-RONG
AU  - YANG, CHUN-CHUN
AU  - YAO, CHUN-HSU
AU  - NI, TIEN
AU  - HO, WEI-CHUAN
AU  - CHEN, YUEH-SHENG
AU  - TU, CHIH-YEN
AU  - CHANG, WEI-CHAO
AU  - WU, YANG-CHANG
AU  - TANG, CHIH-HSIN
AU  - HUANG, HUI-CHI
AU  - HUANG, WEI-CHIEN
AU  - LI, TZONG-SHIUN
TI  - Snail Mucus Enhances Chemosensitivity of Triple-negative Breast Cancer <em>Via</em> Activation of the Fas Pathway
AID  - 10.21873/anticanres.15542
DP  - 2022 Feb 01
TA  - Anticancer Research
PG  - 845--855
VI  - 42
IP  - 2
4099  - http://ar.iiarjournals.org/content/42/2/845.short
4100  - http://ar.iiarjournals.org/content/42/2/845.full
SO  - Anticancer Res2022 Feb 01; 42
AB  - Background/Aim: The poor prognosis and chemoresistance of patients with triple-negative breast cancer (TNBC) urge the development of new therapeutic strategies. Snail mucus has shown its ability against inflammation, a process closely related to tumorigenesis, suggesting a potential anti-cancer activity. Materials and Methods: The effect and mechanisms of snail mucus on cell viability were determined by IncuCyte Live-cell analysis and molecular biological methods. The anti-cancer fractions of snail mucus were isolated and identified by medium pressure liquid chromatography (MPLC) and nuclear magnetic resonance (NMR) spectrometry analysis. Results: Snail mucus significantly decreased the viability of TNBC cells with relatively lower cytotoxicity to normal breast epithelial cells and enhanced their response to chemotherapy through activation of Fas signaling by suppressing nucleolin. Two peptide fractions have been identified as the anti-cancer ingredients of the snail mucus. Conclusion: Snail mucus can induce programmed cell death via the extrinsic apoptotic pathway and has therapeutic potential by achieving a chemo-sensitizing effect in TNBCs.