TY - JOUR T1 - A Novel Injectable Hydrogel Matrix Loaded With 90Y Microspheres for the Treatment of Solid Tumors JF - Anticancer Research JO - Anticancer Res SP - 827 LP - 836 DO - 10.21873/anticanres.15540 VL - 42 IS - 2 AU - ANTONINO AMATO AU - PIER LUIGI CARRIERO AU - GORDON MCVIE AU - GIOVANNI PAGANELLI Y1 - 2022/02/01 UR - http://ar.iiarjournals.org/content/42/2/827.abstract N2 - Background/Aim: The need to concentrate the anti-tumoral activity of 90Y only to the targeted tumor, while minimizing its off-target effects, led to the development of an innovative device (BAT-90) composed of a hydrogel matrix and 90Y microspheres. Materials and Methods: This in vivo randomized study was planned to assess the efficacy, safety, and biodistribution of BAT-90 in 46 rabbits implanted with a VX2 tumor. The effects of BAT-90 were compared to those of 90Y microspheres and the hydrogel matrix. Results: BAT-90 localized effectively the 90Y radiation in the injection site, minimizing dispersion of the microspheres in the target and distant organs of the treated animals. Conclusion: BAT-90 can be administered as an adjuvant treatment to clear surgical margins from any potential minimal residual disease, or as an alternative to other loco-regional treatments for non-resectable tumors. ER -