PT - JOURNAL ARTICLE AU - RYO KURASHINA AU - KIYOHIRO ANDO AU - MASAHARU INOUE AU - KEITA IZUMI AU - RIKO MARUYAMA AU - KOUKI MITANI AU - HISANORI TAKENOBU AU - MASAYUKI HARUTA AU - TOSHIHIKO IIZUKA AU - TAKEHIKO KAMIJO AU - YUKIO KAGEYAMA TI - Platelet-to-Lymphocyte Ratio Predicts the Efficacy of Pembrolizumab in Patients With Urothelial Carcinoma AID - 10.21873/anticanres.15576 DP - 2022 Feb 01 TA - Anticancer Research PG - 1131--1136 VI - 42 IP - 2 4099 - http://ar.iiarjournals.org/content/42/2/1131.short 4100 - http://ar.iiarjournals.org/content/42/2/1131.full SO - Anticancer Res2022 Feb 01; 42 AB - Background/Aim: This study aimed to determine useful predictive factors for selecting patients with advanced urothelial carcinoma (UC) who might benefit clinically from treatment with pembrolizumab. Patients and Methods: We retrospectively analyzed 54 patients who underwent pembrolizumab treatment for UC. The hemoglobin, albumin, lymphocyte and platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were calculated as indices of systemic inflammatory response, and the relationships between these scores and the initial tumor response or overall survival, as well as other clinicopathological factors, were assessed. Results: High NLR and PLR were associated with a poor initial tumor response to pembrolizumab. A HALP score <30.05 and a PLR ≥173.73 were associated with worse overall survival. In the multivariate Cox regression analysis, a high PLR was a significant independent prognostic factor for unfavorable outcomes. Conclusion: A high pretreatment PLR may be a valuable indicator for choosing therapy other than pembrolizumab in patients with advanced UC.