TY - JOUR T1 - Risk Factors for Hepatic Toxicity of High-dose Methotrexate in Patients With Osteosarcoma JF - Anticancer Research JO - Anticancer Res SP - 1043 LP - 1050 DO - 10.21873/anticanres.15565 VL - 42 IS - 2 AU - KENTARO ABE AU - AYAKO MAEDA-MINAMI AU - TAKU ISHIZU AU - SHINTARO IWATA AU - EISUKE KOBAYASHI AU - TATSUNORI SHIMOI AU - YOHEI KAWANO AU - HIRONOBU HASHIMOTO AU - MASAKAZU YAMAGUCHI AU - TETSUYA FURUKAWA AU - SATORU MIYAZAKI AU - YASUNARI MANO Y1 - 2022/02/01 UR - http://ar.iiarjournals.org/content/42/2/1043.abstract N2 - Background/Aim: High-dose methotrexate (HD-MTX) is widely used to treat osteosarcoma. However, some patients develop hepatic toxicity, leading to dose modification and delays in the scheduled chemotherapy. The present study aimed to identify the risk factors of hepatotoxicity in patients with osteosarcoma. Patients and Methods: We conducted a retrospective study of patients with osteosarcoma treated with HD-MTX between January 2014 and June 2020 at the National Cancer Center Hospital, Japan. The risk factors for MTX-induced hepatotoxicity (≥grade 3) were identified using multivariate logistic regression analysis. Results: The final analysis included 88 courses of 36 patients. Hepatotoxicity occurred in 51 (58.0%) of the 88 courses. Female sex, MTX dose (>10.2 g/m2), and serum calcium concentration (>9.3 mg/dl) were identified as risk factors for HD-MTX-induced hepatotoxicity. Conclusion: Identifying the risk factors of HD-MTX-induced hepatotoxicity may contribute to improvements in the safety and management of HD-MTX therapy. ER -