RT Journal Article SR Electronic T1 A Systematic Review of Minimally Invasive Versus Open Radical Antegrade Modular Pancreatosplenectomy for Pancreatic Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 653 OP 660 DO 10.21873/anticanres.15523 VO 42 IS 2 A1 KOSEI TAKAGI A1 YUZO UMEDA A1 RYUICHI YOSHIDA A1 TAKAHITO YAGI A1 TOSHIYOSHI FUJIWARA YR 2022 UL http://ar.iiarjournals.org/content/42/2/653.abstract AB Background/Aim: The aim of this study was to investigate surgical and oncological outcomes of minimally invasive (MI) and open radical antegrade modular pancreatosplenectomy (RAMPS) for the treatment of left-sided pancreatic cancer. Materials and Methods: A systematic literature search and meta-analyses were performed focusing on short-term surgical oncology of MI- and open-RAMPS. Results: A total of seven studies with 423 patients were included in this review. The equivalent short-term and long-term outcomes of the groups were confirmed. The results of meta-analyses found no significant difference in R0 resection rates (OR=1.78, 95%CI=0.76-4.15, p=0.18), although MI-RAMPS was associated with a smaller number of dissected lymph nodes (MD=–3.14, 95%CI=–4.75 - –1.53, p<0.001) and lymph node metastases (OR=0.55, 95%CI=0.31-0.97, p=0.04). Conclusion: MI-RAMPS could provide surgically and oncologically feasible outcomes for well-selected left-sided pancreatic cancer as compared to open-RAMPS. However, further high-level evidence should be needed to confirm survival benefits following MI-RAMPS.