PT - JOURNAL ARTICLE AU - NAOKI SHIBATA AU - KAZUYOSHI KAWAKAMI AU - SHIMIZU HISANORI AU - KAZUO KOBAYASHI AU - MAYU YUNOKAWA AU - HIROYUKI KANAO AU - IORI TAKI AU - REMI MURASE AU - DAISUKE KAMEI AU - MASAKAZU YAMAGUCHI TI - Investigation of Hypersensitivity Reactions in Carboplatin Desensitization Therapy AID - 10.21873/anticanres.15571 DP - 2022 Feb 01 TA - Anticancer Research PG - 1091--1097 VI - 42 IP - 2 4099 - http://ar.iiarjournals.org/content/42/2/1091.short 4100 - http://ar.iiarjournals.org/content/42/2/1091.full SO - Anticancer Res2022 Feb 01; 42 AB - Background/Aim: Carboplatin is a key drug in the treatment of ovarian cancer, but hypersensitivity reactions (HSRs) may occur with repeated use. Patients and Methods: Thirty-seven ovarian cancer patients treated with carboplatin desensitization therapy were reviewed retrospectively. The treatment completion rate and toxicity were examined. Results: The carboplatin desensitization completion rate was 86.5%. Toxicity was Grade 0, 1, 2, and 3 in 17, 5, 10, and 5 patients, respectively. Erythema was the most frequent toxicity (36.8%), most commonly affecting the arm (23.5%). Furthermore, all HSRs were classified into: skin, respiratory, digestive, circulatory, and neurological. The completion rate of desensitization was significantly lower in patients with two or more target organs affected (p<0.001). Conclusion: The main symptoms of HSRs, the most common sites of HSRs, and the criteria for discontinuing desensitization therapy identified in this study are useful information for the safe implementation of carboplatin desensitization therapy.