PT  - JOURNAL ARTICLE
AU  - TOMOYOSHI TAKENAKA
AU  - TETSUZO TAGAWA
AU  - MIKIHIRO KOHNO
AU  - NAOKI HARATAKE
AU  - FUMIHIKO KINOSHITA
AU  - YUKI ONO
AU  - SHO WAKASU
AU  - YUKA OKU
AU  - MASAKI MORI
TI  - Consideration of the Optimal Surgical Procedure Based on the Risk of Recurrence in Clinical Stage 0 or IA Lung Adenocarcinoma
AID  - 10.21873/anticanres.15577
DP  - 2022 Feb 01
TA  - Anticancer Research
PG  - 1137--1142
VI  - 42
IP  - 2
4099  - http://ar.iiarjournals.org/content/42/2/1137.short
4100  - http://ar.iiarjournals.org/content/42/2/1137.full
SO  - Anticancer Res2022 Feb 01; 42
AB  - Background/Aim: Sublobar resection is widely performed for early-stage non-small cell lung cancer in the clinical setting. This study evaluated the optimal surgical procedures of clinical stage 0 or IA adenocarcinoma from the perspective of recurrence. Patients and Methods: A total of 508 lung adenocarcinoma patients diagnosed as c-stage 0 or IA were retrospectively investigated. Results: The types of surgical procedures were lobectomy (n=328), segmentectomy (n=73), and wedge resection (n=107). Clinical T descriptors were cTis in 74, cT1mi in 68, cT1a in 94, cT1b in 181 and cT1c in 91 patients. Recurrence was observed in 46 cases (9%), including 3 (3.1%) with cT1a, 23 (12.7%) with cT1b and 20 (22.0%) with cT1c. The patients who received sublobar resection developed recurrence more often than the patients who received lobectomy among cT1b cases (10.1% vs. 21.4%) and cT1c cases (18.0% vs. 46.2%) (p=0.053 and p=0.023). Conclusion: The cT1b and cT1c cases should be considered for lobectomy to prevent recurrence.