TY - JOUR T1 - Leptomeningeal Metastases of the Spine: A Systematic Review JF - Anticancer Research JO - Anticancer Res SP - 619 LP - 628 DO - 10.21873/anticanres.15519 VL - 42 IS - 2 AU - PAOLO PALMISCIANO AU - NAVRAJ S. SAGOO AU - ABDURRAHMAN F. KHARBAT AU - YVES J. KENFACK AU - OTHMAN BIN ALAMER AU - GIANLUCA SCALIA AU - GIUSEPPE E. UMANA AU - SALAH G. AOUN AU - ALI S. HAIDER Y1 - 2022/02/01 UR - http://ar.iiarjournals.org/content/42/2/619.abstract N2 - Background/Aim: Leptomeningeal metastases (LMs) of the spine have complex management. We reviewed the literature on spine LMs. Materials and Methods: PubMed, EMBASE, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of spine LMs. Results: We included 46 studies comprising 72 patients. The most frequent primary tumors were lung (19.4%) and breast cancers (19.4%). Median time from primary tumors was 12 months (range=0-252 months). Cauda equina syndrome occurred in 34 patients (48.6%). Nodular spine LMs (63.6%) were more frequent. Concurrent intracranial LMs were present in 27 cases (50.9%). Cerebrospinal fluid cytology was positive in 31 cases (63.6%). Cases were managed using palliative steroids (73.6%) with locoregional radiotherapy (55.6%) chemotherapy (47.2%), or decompressive laminectomy (8.3%). Post-treatment symptom improvement (32%) and favorable radiological response (28.3%) were not different based on treatment (p=0.966; p=0.727). Median overall-survival was 3 months (range=0.3-60 months), not significantly different between radiotherapy and chemotherapy (p=0.217). Conclusion: Spine LMs have poor prognoses. Radiotherapy, chemotherapy, and surgery are only palliative, as described for intracranial LMs. ER -