RT Journal Article
SR Electronic
T1 Peritumoral Hyperintensity at Hepatobiliary Phase Gadoxetic Acid–enhanced MRI in Hepatic Neuroendocrine Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 911
OP 917
DO 10.21873/anticanres.15549
VO 42
IS 2
A1 NOBUHIRO FUJITA
A1 ATSUHIKO HANDA
A1 JINHA M. PARK
YR 2022
UL http://ar.iiarjournals.org/content/42/2/911.abstract
AB Background/Aim: To identify the imaging and clinical features of hepatic neuroendocrine tumors (NETs) associated with peritumoral hyperintensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging. Patients and Methods: Fifty-seven patients with hepatic NETs were enrolled. Based on the degree of peritumoral hyperintensity, patients were divided into three groups: group 0 (no peritumoral hyperintensity), group 1 (lower peritumoral hyperintensity), and group 2 (higher peritumoral hyperintensity). The imaging and clinical findings were compared among the three groups. Results: Apparent diffusion coefficient (ADC) values of group 2 were significantly lower than those of group 0 and group 1. Atypical (cholangiocarcinoma-like) enhancement pattern in the arterial phase was significantly more frequently observed in group 2 as compared to that in group 0 and group 1. Group 2 patients showed significantly poorer progression-free survival than group 0 patients. Conclusion: Hepatic NETs with greater peritumoral hyperintensity exhibit greater malignant potential.