RT Journal Article SR Electronic T1 Minimally Invasive Transcervical Esophagectomy With Mediastinal Lymphadenectomy for Cancer. A Comparison With Standardized Techniques JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 675 OP 680 DO 10.21873/anticanres.15526 VO 42 IS 2 A1 SPYRIDON DAVAKIS A1 ALEXANDROS CHARALABOPOULOS A1 ELEANDROS KYROS A1 PANAGIOTIS SAKARELLOS A1 GERASIMOS TSOUROUFLIS A1 DIMITRIOS DIMITROULIS A1 NIKOLAOS NIKITEAS YR 2022 UL http://ar.iiarjournals.org/content/42/2/675.abstract AB Pulmonary complications remain the most common problem following transthoracic esophagectomy. Minimally invasive approach has significantly improved clinical outcomes; however, respiratory distress is still significant. Minimally invasive transcervical esophagectomy with mediastinal lymphadenectomy avoids thoracic access, which may decrease pulmonary complications. Transcervical esophagectomy refers to transcervical esophageal mobilization and mediastinal lymphadenectomy followed by a transhiatal gastric and distal-esophageal mobilization, abdominal and lower mediastinal lymphadenectomy. Adoption of innovative minimally invasive techniques for the transcervical or transhiatal approach, such as laparoscopy or robotic-assisted mediastinoscopy have made possible transmediastinal approach for radical esophagectomy. This novel approach with avoidance of thoracotomy or thoracoscopy can omit one lung ventilation as in transthoracic esophagectomy. Patients with previous thoracic surgery, impaired respiratory system, and major comorbidities, who are unable to undergo transthoracic esophagectomy, become candidates for radical esophagectomy with promising results. Minimally invasive transcervical esophagectomy for esophageal cancer is a safe and feasible approach and may be a valuable alternative with promising clinical and oncological outcomes.