RT Journal Article
SR Electronic
T1 Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2561
OP 2565
VO 25
IS 3C
A1 ELEFTHERIOS VAIRAKTARIS
A1 CHRISTOS YAPIJAKIS
A1 JÖRG WILTFANG
A1 JUTTA RIES
A1 ANTONIS VYLLIOTIS
A1 SPYRIDOULA DERKA
A1 STAVROS VASILIOU
A1 FRIEDRICH W. NEUKAM
YR 2005
UL http://ar.iiarjournals.org/content/25/3C/2561.abstract
AB Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore, a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods: In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia (p<0.001). Conclusion: There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in oncogenesis in the oral region.