TY - JOUR T1 - Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer? JF - Anticancer Research JO - Anticancer Res SP - 2561 LP - 2565 VL - 25 IS - 3C AU - ELEFTHERIOS VAIRAKTARIS AU - CHRISTOS YAPIJAKIS AU - JÖRG WILTFANG AU - JUTTA RIES AU - ANTONIS VYLLIOTIS AU - SPYRIDOULA DERKA AU - STAVROS VASILIOU AU - FRIEDRICH W. NEUKAM Y1 - 2005/05/01 UR - http://ar.iiarjournals.org/content/25/3C/2561.abstract N2 - Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore, a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods: In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia (p<0.001). Conclusion: There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in oncogenesis in the oral region. ER -