RT Journal Article
SR Electronic
T1 Neoadjuvant Chemotherapy in Breast Cancer: Which Diagnostic Procedures Can be Used?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2519
OP 2525
VO 25
IS 3C
A1 C.R. LOEHBERG
A1 M.P. LUX
A1 S. ACKERMANN
A1 U.G. POEHLS
A1 M.R. BANI
A1 R. SCHULZ-WENDTLAND
A1 T. PAPADOPOULOS
A1 M. SCHMUCKER
A1 M.W. BECKMANN
A1 P.A. FASCHING
YR 2005
UL http://ar.iiarjournals.org/content/25/3C/2519.abstract
AB Background: To improve breast cancer treatment, the evaluation of predictive factors is in the focus of clinical research. Significant discrepancies between the clinical assessment of response to neoadjuvant chemotherapy (NACT) and the pathological assessment of response from post-therapy surgical specimens have been demonstrated. We focused on comparing the value of various diagnostic methods used in medical routine. Patients and Methods: A clinical evaluation of the primary tumour and regional lymph nodes before and after NACT was performed in 139 patients by physical examination, sonography and mammography. Results: Mammography and physical examination correlated best with pathological findings in the measurement of the tumour, whereas sonography was the most accurate predictor of the status for axillary lymph nodes. Conclusion: Mammography and physical examination are the best non-invasive predictors of the real size of the primary breast cancer, whereas sonography correlates better with the proven status of axillary lymph nodes.