RT Journal Article
SR Electronic
T1 Sulfotransferase1A1 and Risk of Postmenopausal Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2515
OP 2517
VO 25
IS 3C
A1 PIIHA-LOTTA JEREVALL
A1 AHMAD AHMADI
A1 MALIN BERGMAN
A1 OLLE STAL
A1 STEN WINGREN
YR 2005
UL http://ar.iiarjournals.org/content/25/3C/2515.abstract
AB The detoxification enzyme sulfotransferase1A1 (SULT1A1) is implicated in the inactivation of estrogens and the activation of promutagens and procarcinogens. SULT1A1 activity varies among individuals, and this difference in phenotype is, in part, controlled by genetic polymorphism (Arg→His in codon 213). It is hypothesized that the His allele contributes to the risk of postmenopausal breast cancer. Frequencies of the Arg/His alleles were estimated in 229 postmenopausal breast cancer patients and 227 age-matched controls using a PCR-RFLP assay. Allele frequencies and genotype distributions were not statistically different between postmenopausal breast cancer patients and the population-based controls, i.e. neither of the alleles is associated with an increased risk of breast cancer in the present study.