TY - JOUR T1 - Vinorelbine and Cisplatin in Advanced Squamous Cell Carcinoma of the Cervix: The South African Experience JF - Anticancer Research JO - Anticancer Res SP - 2489 LP - 2492 VL - 25 IS - 3C AU - LOUIS GOEDHALS AU - GEOFFREY FALKSON AU - BRENDA LYNN SMITH AU - CARLA ISADORA FALKSON AU - JAMAL GASMI AU - ANDRIES LATEGAN AU - JEAN-PHILIPPE BURILLON AU - PATRICIA HIS Y1 - 2005/05/01 UR - http://ar.iiarjournals.org/content/25/3C/2489.abstract N2 - Background: This phase II trial was performed to assess the activity and safety of the cisplatin and vinorelbine combination in patients with advanced cervical carcinoma. Patients and Methods: Forty-two patients with advanced cervical cancer were included in the study to receive vinorelbine at 30 mg/m2 on d 1 and d 8 and cisplatin 100 mg/m2 on day 1 every 4 weeks. Results: Thirty-seven patients were evaluable for response and 40 patients for tolerance. Twenty-four patients (64.8%) achieved objective responses. The median duration of response was 17.5 months (range 2.5-57 months), median time to progression was 13.2 months (range 0.4-57 months) and median survival was 20.6 months (range 0.4-55 months). This regimen was well-tolerated; no WHO grade 4 neutropenia was observed, grade 3 nausea and vomiting occured in 50% of patients and grade 2 peripheral neuropathy in 5% of patients. Conclusion: Vinorelbine-cisplatin is an active and well-tolerated regimen in advanced cervical carcinoma. ER -