TY - JOUR T1 - Free / Total Prostate Specific Antigen Ratio for Prostate Cancer Detection: A Prospective Blind Study JF - Anticancer Research JO - Anticancer Res SP - 2439 LP - 2443 VL - 25 IS - 3C AU - CHI-REI YANG AU - CHUNG-KNANG SU AU - KUN-YUAN CHIU AU - HAO-CHUNG HO AU - YEN-CHUAN OU AU - CHENG-LI CHENG AU - HUEI LEE Y1 - 2005/05/01 UR - http://ar.iiarjournals.org/content/25/3C/2439.abstract N2 - Background: We conducted this prospective study to evaluate the ability of the percentage of free PSA (% f/t PSA) to improve the specificity of prostate cancer (PC) detection. Materials and Methods: Seven hundred and eighty-five patients with serum PSA levels between 4 and 25 ng/ml underwent sextant biopsies of the prostate. The % f/t PSA was analyzed for the sensitivity, specificity and positive predictive values. Results: The mean % f/t PSA of the 169 patients with PC was 18.0±7.7 and was significantly (p<0.0001) lower than that of the 616 patients who had histologically benign biopsy specimens, with a mean % f/t PSA of 26.6±9.7. Using 30% f/t PSA as the cut-off eliminated 34.4 % of the negative biopsies while still detecting 93.4% of the carcinomas. Conclusion: The optimal cut-off value of 30% f/t PSA may be applied as reference using the Cis bio international assay for PC detection. ER -