RT Journal Article
SR Electronic
T1 Successful Treatment of Hypertrophic Osteoarthropathy by Gefitinib in a Case with Lung Adenocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2435
OP 2438
VO 25
IS 3C
A1 MITSUTOSHI HAYASHI
A1 AKIHIKO SEKIKAWA
A1 ARIKO SAIJO
A1 WAKANA TAKADA
A1 ISAO YAMAWAKI
A1 SHIN-ICHIRO OHKAWA
YR 2005
UL http://ar.iiarjournals.org/content/25/3C/2435.abstract
AB Hypertrophic osteoarthropathy is an important manifestation of lung carcinoma, particularly in a non-small cell tumor, and hampers quality of life. Although removal of the primary tumor usually resolves this syndrome, effective treatment in patients with advanced lung carcinoma has not been established. Recently, an orally active, selective epidermal growth factor receptor tyrosine kinase (EGFR) inhibitor (“Gefitinib”) provided clinical anti-tumor activity. We describe a 71-year-old male smoker with cough, who presented with clubbed fingers. A transbronchial lung biopsy (stage T2N3M1-IV) on a cavity lesion in the left lower lobe showed the features of adenocarcinoma, while bone scintigram revealed bilaterally symmetrical abnormal uptakes in the lower extremities, suggesting secondary hypertrophic osteoarthropathy. The serum level of growth hormone was increased to 1.42 ng/ml. Chemotherapy (cisplatin, vinorelbine) was not effective. Gefitinib, as a second-line therapy, induced disappearance of the abnormal accumulation on bone scintigraphy and decrease of the cavity in the lung and of serum growth hormone. The presented case suggests that the EGFR inhibitor might be a promising option for the treatment of hypertrophic osteoarthropathy with advanced lung adenocarcinoma.