RT Journal Article
SR Electronic
T1 Gastric Lavage Malignant Cells (yGL) and Hypohemoglobinemia (yAnemia) as New Systems of Tumor Regression Grading and Prognostic Prediction for Gastric Cancer After Neoadjuvant Treatment
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1019
OP 1027
DO 10.21873/anticanres.13208
VO 39
IS 2
A1 EDOARDO VIRGILIO
A1 ENRICO GIARNIERI
A1 MARIA ROSARIA GIOVAGNOLI
A1 MONICA MONTAGNINI
A1 ANTONELLA PROIETTI
A1 ROSARIA D'URSO
A1 ALESSANDRA FEGIZ
A1 PAOLO MERCANTINI
A1 GENOVEFFA BALDUCCI
A1 MARCO CAVALLINI
YR 2019
UL http://ar.iiarjournals.org/content/39/2/1019.abstract
AB Background/Aim: Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpose of this study was to examine endogastric cytopathology and hemoglobin level count as new features, potentially useful for GC patients after NAC. Patients and Methods: Between April 2012 and October 2018, 21 of 116 patients with resectable GC received NAC and were investigated for the presence of free-floating malignant cells in their gastric lavage (yGL1) and the development of hypohemoglobinia (yAnemia). Results: yGL1 and yAnemia were found in 11 and 12 patients, respectively. yGL1 correlated with the traditional parameters of tumor regression (p=0.0424). Both yGL1 and yAnemia were found to be independent predictive factors of overall and progression-free survival (p≤0.0364). Conclusion: In the light of our results, the yGL1 and yAnemia appear two promising, simple and interesting clinicopathological features which should always be examined for better clarifying GC patients' response to NAC.