TY - JOUR T1 - Gastric Lavage Malignant Cells (yGL) and Hypohemoglobinemia (yAnemia) as New Systems of Tumor Regression Grading and Prognostic Prediction for Gastric Cancer After Neoadjuvant Treatment JF - Anticancer Research JO - Anticancer Res SP - 1019 LP - 1027 DO - 10.21873/anticanres.13208 VL - 39 IS - 2 AU - EDOARDO VIRGILIO AU - ENRICO GIARNIERI AU - MARIA ROSARIA GIOVAGNOLI AU - MONICA MONTAGNINI AU - ANTONELLA PROIETTI AU - ROSARIA D'URSO AU - ALESSANDRA FEGIZ AU - PAOLO MERCANTINI AU - GENOVEFFA BALDUCCI AU - MARCO CAVALLINI Y1 - 2019/02/01 UR - http://ar.iiarjournals.org/content/39/2/1019.abstract N2 - Background/Aim: Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpose of this study was to examine endogastric cytopathology and hemoglobin level count as new features, potentially useful for GC patients after NAC. Patients and Methods: Between April 2012 and October 2018, 21 of 116 patients with resectable GC received NAC and were investigated for the presence of free-floating malignant cells in their gastric lavage (yGL1) and the development of hypohemoglobinia (yAnemia). Results: yGL1 and yAnemia were found in 11 and 12 patients, respectively. yGL1 correlated with the traditional parameters of tumor regression (p=0.0424). Both yGL1 and yAnemia were found to be independent predictive factors of overall and progression-free survival (p≤0.0364). Conclusion: In the light of our results, the yGL1 and yAnemia appear two promising, simple and interesting clinicopathological features which should always be examined for better clarifying GC patients' response to NAC. ER -