@article {HAYASHI2399, author = {MASAYUKI HAYASHI and HIROYUKI TSUCHIYA and NORIO YAMAMOTO and MICHIAKI KARITA and TOSHIHARU SHIRAI and HIDEJI NISHIDA and AKIHIKO TAKEUCHI and KATSURO TOMITA}, title = {Caffeine-potentiated Chemotherapy for Metastatic Carcinoma and Lymphoma of Bone and Soft Tissue}, volume = {25}, number = {3C}, pages = {2399--2405}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {Background: We previously reported that caffeine-potentiated chemotherapy induced significantly good response in patients with musculoskeletal sarcomas. In that series, patients with metastatic carcinoma or lymphoma were treated with caffeine-potentiated chemotherapy. Patients and Methods: Five patients with metastatic carcinoma or lymphoma were treated with caffeine-potentiated chemotherapy. Results: Primary tumors were diagnosed as breast cancer, adenocarcinoma of the lung, clear cell adenocarcinoma of the vagina, diffuse large B-cell lymphoma and gastric cancer. Good responses (gross tumor shrinkage \>30\%, or histologically \>90\% necrosis) to chemotherapy were seen in all five patients. Survival time was \>1 year in all patients, and three out of five patients presented no evidence of local recurrence or metastasis at the final follow-up. Conclusion: Caffeine-potentiated chemotherapy may be of benefit for malignant tumors other than musculoskeletal sarcoma.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/3C/2399}, eprint = {https://ar.iiarjournals.org/content/25/3C/2399.full.pdf}, journal = {Anticancer Research} }