PT  - JOURNAL ARTICLE
AU  - FABIO CAMPODONICO
AU  - GIORGIO CANEPA
AU  - GIACOMO CAPPONI
AU  - LUIGI BOZZO
AU  - MASSIMO MAFFEZZINI
TI  - Intravesical Gemcitabine in Recurrent Superficial Bladder Carcinoma: Preliminary Results on Ablative Efficacy and Tolerability
DP  - 2005 May 01
TA  - Anticancer Research
PG  - 2381--2384
VI  - 25
IP  - 3C
4099  - http://ar.iiarjournals.org/content/25/3C/2381.short
4100  - http://ar.iiarjournals.org/content/25/3C/2381.full
SO  - Anticancer Res2005 May 01; 25
AB  - Background: The ablative potential and toxicity of gemcitabine, administered intravesically in low stage and grade superficial transitional cell carcinoma (TCC), were evaluated. Patients and Methods: Patients with a history of recurrent Ta-T1, G1-G2 bladder TCC were considered eligible for the study. Gemcitabine was administered intravesically at 40 mg/mL concentration (2000 mg in 50 ml saline) in one weekly instillation for 4 consecutive weeks. Fifteen days after the last instillation, patients were submitted to transurethral resection (TUR). Results: Twenty-six patients were evaluable for toxicity, and 20 were evaluable for response, 6 patients being excluded due to toxicity. A complete response was achieved by 10 out of 20 patients (50%), whereas no response was documented in the remainder. Toxicity leading to treatment interruption was grade 3 in 1 patient and grade 2 in 5 patients. Conclusion: Intravesical gemcitabine administered at 40 mg/mL showed the capability of ablating small volume, superficial TCC in 50% of the population under study, with acceptable tolerability.