RT Journal Article SR Electronic T1 Clinicopathological Analysis of Non-B Non-C Hepatocellular Carcinoma Focusing on Cellular Proliferation JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 449 OP 457 DO 10.21873/anticanres.15503 VO 42 IS 1 A1 SHINJI MIZUOCHI A1 JUN AKIBA A1 REIICHIRO KONDO A1 HIRONORI KUSANO A1 TARO SHIOGA A1 KEIICHI KONDO A1 KANA TSUTSUI A1 MASAMICHI NAKAYAMA A1 SACHIKO OGASAWARA A1 YOSHIKI NAITO A1 OSAMU NAKASHIMA A1 HIROHISA YANO YR 2022 UL http://ar.iiarjournals.org/content/42/1/449.abstract AB Background/Aim: Non-B non-C hepatocellular carcinomas (NBNC-HCCs) are larger than hepatitis virus-related HCCs. We conducted a clinicopathological study of patients who underwent curative NBNC-HCC resection, including proliferative activity assessments, such as nuclear grade and Ki-67 labelling index (LI). Materials and Methods: Histopathological findings of 197 patients were examined, including 56 NBNC-HCCs, 45 hepatitis B virus (HBV)-related HCCs (HBV-HCC), and 96 hepatitis C virus (HCV)-related HCCs (HCV-HCC). Results: NBNC-HCCs were significantly larger than HCV-HCCs, but not significantly different from HBV-HCCs. Mitotic counts, nuclear grade, and Ki-67 LI of NBNC-HCCs were not significantly different from those of HCV-HCCs, but were significantly lower than those of HBV-HCCs. Recurrence-free survival was significantly better in the NBNC-HCC group than in the HBV-HCC group in cases with mild liver fibrosis. Conclusion: NBNC-HCCs were significantly larger in diameter, but their nuclear grade or Ki-67 LI were not significantly different from those of other HCCs, suggesting that they do not have a higher proliferative activity.