PT  - JOURNAL ARTICLE
AU  - MALLETT, KATHERINE E.
AU  - ALMUBARAK, SARAH
AU  - CLAXTON, RYAN M.
AU  - FERGUSON, PETER C.
AU  - GRIFFIN, ANTHONY M.
AU  - ROSE, PETER S.
AU  - WUNDER, JAY S.
AU  - TSOI, KIM
AU  - HOUDEK, MATTHEW T.
TI  - Preoperative Risk Factors for Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans
AID  - 10.21873/anticanres.15463
DP  - 2022 Jan 01
TA  - Anticancer Research
PG  - 105--108
VI  - 42
IP  - 1
4099  - http://ar.iiarjournals.org/content/42/1/105.short
4100  - http://ar.iiarjournals.org/content/42/1/105.full
SO  - Anticancer Res2022 Jan 01; 42
AB  - Background/Aim: Dermat of ibrosarcoma protuberans (DFSP) is a soft-tissue sarcoma with a high risk of local recurrence, though typically never metastasizes. DFSP can transform into high-grade fibrosarcoma (DFSP-FS), which has a risk of metastasis. Currently, treatment for DFSP includes Moh’s micrographic surgery (MMS); however, this is not recommended for DFSP-FS. Often, the transformation to DFSP-FS is not recognized until the final histological diagnosis. At that point, wide local excision (WLE) of a previous MMS site can be morbid. As such, we analyzed patient risk factors to allow identification of DFSP-FS transformation at presentation. Patients and Methods: We reviewed 368 (174 female, 194 male) patients with a mean age of 42 years from two sarcoma centers. A total of 319 (87%) patients had a history of DFSP and 49 (13%) had DFSP-FS. Results: When comparing patients with a DFSP to those with a DFSP-FS, patients with a DFSP-FS were more likely (p<0.05) to be older, female and with larger tumors. A painful mass and rapidly enlarging mass were associated with DFSP-FS. Conclusion: Patients who presented with DFSP-FS were found to typically have a larger, painful, and growing mass. Patients with these features should be referred for WLE over MMS at presentation.