<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MALLETT, KATHERINE E.</style></author><author><style face="normal" font="default" size="100%">ALMUBARAK, SARAH</style></author><author><style face="normal" font="default" size="100%">CLAXTON, RYAN M.</style></author><author><style face="normal" font="default" size="100%">FERGUSON, PETER C.</style></author><author><style face="normal" font="default" size="100%">GRIFFIN, ANTHONY M.</style></author><author><style face="normal" font="default" size="100%">ROSE, PETER S.</style></author><author><style face="normal" font="default" size="100%">WUNDER, JAY S.</style></author><author><style face="normal" font="default" size="100%">TSOI, KIM</style></author><author><style face="normal" font="default" size="100%">HOUDEK, MATTHEW T.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Preoperative Risk Factors for Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022-01-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">105-108</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.15463</style></doi><volume><style face="normal" font="default" size="100%">42</style></volume><issue><style face="normal" font="default" size="100%">1</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Dermat of ibrosarcoma protuberans (DFSP) is a soft-tissue sarcoma with a high risk of local recurrence, though typically never metastasizes. DFSP can transform into high-grade fibrosarcoma (DFSP-FS), which has a risk of metastasis. Currently, treatment for DFSP includes Moh’s micrographic surgery (MMS); however, this is not recommended for DFSP-FS. Often, the transformation to DFSP-FS is not recognized until the final histological diagnosis. At that point, wide local excision (WLE) of a previous MMS site can be morbid. As such, we analyzed patient risk factors to allow identification of DFSP-FS transformation at presentation. Patients and Methods: We reviewed 368 (174 female, 194 male) patients with a mean age of 42 years from two sarcoma centers. A total of 319 (87%) patients had a history of DFSP and 49 (13%) had DFSP-FS. Results: When comparing patients with a DFSP to those with a DFSP-FS, patients with a DFSP-FS were more likely (p&lt;0.05) to be older, female and with larger tumors. A painful mass and rapidly enlarging mass were associated with DFSP-FS. Conclusion: Patients who presented with DFSP-FS were found to typically have a larger, painful, and growing mass. Patients with these features should be referred for WLE over MMS at presentation.</style></abstract></record></records></xml>