TY - JOUR T1 - Preoperative Risk Factors for Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans JF - Anticancer Research JO - Anticancer Res SP - 105 LP - 108 DO - 10.21873/anticanres.15463 VL - 42 IS - 1 AU - KATHERINE E. MALLETT AU - SARAH ALMUBARAK AU - RYAN M. CLAXTON AU - PETER C. FERGUSON AU - ANTHONY M. GRIFFIN AU - PETER S. ROSE AU - JAY S. WUNDER AU - KIM TSOI AU - MATTHEW T. HOUDEK Y1 - 2022/01/01 UR - http://ar.iiarjournals.org/content/42/1/105.abstract N2 - Background/Aim: Dermat of ibrosarcoma protuberans (DFSP) is a soft-tissue sarcoma with a high risk of local recurrence, though typically never metastasizes. DFSP can transform into high-grade fibrosarcoma (DFSP-FS), which has a risk of metastasis. Currently, treatment for DFSP includes Moh’s micrographic surgery (MMS); however, this is not recommended for DFSP-FS. Often, the transformation to DFSP-FS is not recognized until the final histological diagnosis. At that point, wide local excision (WLE) of a previous MMS site can be morbid. As such, we analyzed patient risk factors to allow identification of DFSP-FS transformation at presentation. Patients and Methods: We reviewed 368 (174 female, 194 male) patients with a mean age of 42 years from two sarcoma centers. A total of 319 (87%) patients had a history of DFSP and 49 (13%) had DFSP-FS. Results: When comparing patients with a DFSP to those with a DFSP-FS, patients with a DFSP-FS were more likely (p<0.05) to be older, female and with larger tumors. A painful mass and rapidly enlarging mass were associated with DFSP-FS. Conclusion: Patients who presented with DFSP-FS were found to typically have a larger, painful, and growing mass. Patients with these features should be referred for WLE over MMS at presentation. ER -