RT Journal Article
SR Electronic
T1 Mac-2 Binding Protein Glycosylation Isomer as a Prognostic Marker for Hepatocellular Carcinoma With Sustained Virological Response
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 245
OP 251
DO 10.21873/anticanres.15479
VO 42
IS 1
A1 HARIMOTO, NORIFUMI
A1 ITOH, SHINJI
A1 YAMANAKA, TAKAHIRO
A1 HAGIWARA, KEI
A1 ISHII, NORIHIRO
A1 TSUKAGOSHI, MARIKO
A1 WATANABE, AKIRA
A1 ARAKI, KENICHIRO
A1 YOSHIZUMI, TOMOHARU
A1 SHIRABE, KEN
YR 2022
UL http://ar.iiarjournals.org/content/42/1/245.abstract
AB Background/Aim: Mac2-binding protein glycosylation isomer (M2BPGi) is a non-invasive marker for assessing liver fibrosis. This was a retrospective study investigating whether M2BPGi predicts recurrence of hepatocellular carcinoma (HCC) after hepatectomy in patients with HCC who achieved a sustained virological response (SVR). Patients and Methods: We retrospectively reviewed the clinicopathological factors from 60 patients who underwent hepatectomy for HCC after achieving a SVR. We divided all patients into high M2BPGi and low M2BPGi groups and analyzed the clinicopathological and surgical outcomes. Results: High M2BPGi (>1.54, n=23) was significantly associated with lower serum albumin, higher ICGR15, higher Fib-4 index, large blood loss, and worse recurrence-free survival compared to low M2BPGi (≤1.54, n=37). Multivariate analysis identified high M2BPGi and large tumor size as being associated with reduced recurrence-free survival. Multivariate analysis identified lower serum albumin, larger tumor size and higher DCP as associated with reduced overall survival. There was no difference regarding recurrence pattern. Conclusion: Preoperative M2BPGi is a useful biomarker for HCC recurrence after hepatectomy for SVR-HCC.