TY - JOUR T1 - Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 355 LP - 362 DO - 10.21873/anticanres.15493 VL - 42 IS - 1 AU - IMAN M. TALAAT AU - EMAN ABU-GHARBIEH AU - AMAL HUSSEIN AU - MAHMOOD HACHIM AU - ISRAA SOBHY AU - MOHAMED ELADL AU - WASEEM EL-HUNEIDI Y1 - 2022/01/01 UR - http://ar.iiarjournals.org/content/42/1/355.abstract N2 - Background/Aim: Renal cell carcinoma (RCC) is among the most common renal malignancies and requires reliable biomarkers for optimum diagnosis and prognosis. Copines are a family of calcium-dependent phospholipid-binding proteins that were reported to be associated with various cancers. We aimed to investigate the prognostic value of Copines 1 and 3 in RCC patients. Materials and Methods: Copines 1 and 3 bioinformatics analysis and immunohistochemical (IHC) staining were performed on patients with RCC. Results: The findings revealed significant association between Copine 1 expression and the patients’ age, nuclear grade, and tumor stage. Bioinformatics analysis showed a similar trend for the mRNA expression of CPNE1, the gene that encodes Copine 1. Interestingly, results revealed a positive association between Copine 1 and both EphA and Ki-67 expression levels. Noteworthy, there was no significant association between Copine 3 expression and any parameters. Conclusion: Copine 1 may be used as an independent biomarker or in combination with both EphA2 and Ki-67 to predict disease outcome. ER -