RT Journal Article SR Electronic T1 Health-related Quality of Life in Intermediate- or High-risk Patients Treated With Radical External Radiotherapy and Adjuvant Docetaxel for Localized Prostate Cancer: A Randomized, Phase III SPCG-13 Study JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 87 OP 92 DO 10.21873/anticanres.15460 VO 42 IS 1 A1 MIIKKA LEHTONEN A1 JORMA SORMUNEN A1 MARIE HJÄLM-ERIKSSON A1 CAMILLA THELLENBERG-KARLSSON A1 TEPPO HUTTUNEN A1 CLAES GINMAN A1 PIRKKO-LIISA KELLOKUMPU-LEHTINEN A1 On Behalf of the Investigators of the Scandinavian Prostate Cancer Group Study No 13 YR 2022 UL http://ar.iiarjournals.org/content/42/1/87.abstract AB Background/Aim: The goal of this study was to investigate whether health-related quality of life (HRQoL) was affected in patients with high- or intermediate-risk localized prostate cancer treated with docetaxel following radiation therapy (RT). Patients and Methods: A total of 376 patients treated with RT and androgen deprivation were randomized to receive 6 cycles of docetaxel 75 mg/m2 (N=188, Arm A) or surveillance (N=188, Arm B). FACT-P HRQoL questionnaires were gathered at baseline, six months and 1, 2 and 4 years after randomization. The data were analysed using analysis of covariance. Results: FACT-P scores decreased in Arm A at the end of treatment and remained unchanged in Arm B (p<0.0001). The HRQoL scores in Arm A matched Arm B in the 1-year follow-up (p=0.0528) and remained similar in further follow-up. Conclusion: Docetaxel transiently decreased HRQoL during chemotherapy but not after treatment for up to four years of follow-up.