RT Journal Article
SR Electronic
T1 Fractal Dimension as a Prognostic Factor for Laryngeal Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2141
OP 2144
VO 25
IS 3B
A1 ALEXANDER DELIDES
A1 IOANNIS PANAYIOTIDES
A1 ATHANASIOS ALEGAKIS
A1 ASPASIA KYROUDI
A1 CONSTANTINOS BANIS
A1 AIKATERINI PAVLAKI
A1 EMMANOUEL HELIDONIS
A1 CHRISTOS KITTAS
YR 2005
UL http://ar.iiarjournals.org/content/25/3B/2141.abstract
AB Background: Based on the hypothesis that Fractal Dimension (FD) reflects heterogeneity of tumor tissue, we performed an image analysis study to calculate FD of tissue specimens from patients with laryngeal carcinomas in order to investigate its prognostic value. Materials and Methods: Laryngectomy specimens from 52 patients, who had previously undergone total laryngectomy for squamous cell carcinomas, were examined and their history files reviewed. Ten patients were lost from follow-up. Fractal Analysis software was used to estimate FD of histology sections by the box-counting method. FD of carcinomatous areas was correlated with survival. Results: Patients with a FD lower than the median value of the sample, estimated in sections of carcinomas, had statistically significant higher survival rates. Conclusion: Within the sample of patients studied, FD could be used as a prognostic factor. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved