%0 Journal Article %A RYO-ICHI YOSHIMURA %A KAZUMA TODA %A HIROSHI WATANABE %A ATSUSHI KAIDA %A HIROYUKI HARADA %A TAKAHIRO ASAKAGE %A MASAHIKO MIURA %T Efficacy and Safety of Induction Chemotherapy and/or External Beam Radiotherapy Followed by Brachytherapy in Patients With Tongue Cancer %D 2021 %R 10.21873/anticanres.15446 %J Anticancer Research %P 6259-6266 %V 41 %N 12 %X Background/Aim: To evaluate the outcomes of induction chemotherapy and/or external beam radiotherapy (EBRT) followed by brachytherapy (BT) in patients with tongue cancer who had a waiting period for BT or a large tumor that was not suitable for BT. Patients and Methods: As an induction therapy, chemotherapy with tegafur/gimeracil/oteracil (S-1), EBRT or both S-1 chemotherapy and EBRT was prescribed. BT was performed using Au-198 grains or Ir-192 pins. Local control (LC), lymph node metastasis-free survival (LNMFS), overall survival (OS), and complication rates were calculated. Results: Forty-nine patients were enrolled in this study. The 3-year LC, LNMFS, and OS rates for cT1-2 patients were 84%, 45%, and 69%, respectively. The 3-year LC, LNMFS, and OS rates for cT3 patients were 77%, 58%, and 79%, respectively. The incidence of Grade 3 or 4 complications was 6%. Conclusion: Induction therapy contributed to the efficacy of the subsequent BT in LC rate. %U https://ar.iiarjournals.org/content/anticanres/41/12/6259.full.pdf