RT Journal Article
SR Electronic
T1 Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2043
OP 2048
VO 25
IS 3B
A1 WASOWSKA, MALGORZATA
A1 OSZCZAPOWICZ, IRENA
A1 WIETRZYK, JOANNA
A1 OPOLSKI, ADAM
A1 MADEJ, JANUSZ
A1 DZIMIRA, STANISLAW
A1 OSZCZAPOWICZ, JANUSZ
YR 2005
UL http://ar.iiarjournals.org/content/25/3B/2043.abstract
AB In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin, as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these analogs were significantly lower, with LD50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with a single dose of 75% of the LD50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of the parent drugs. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved