PT - JOURNAL ARTICLE AU - WASOWSKA, MALGORZATA AU - OSZCZAPOWICZ, IRENA AU - WIETRZYK, JOANNA AU - OPOLSKI, ADAM AU - MADEJ, JANUSZ AU - DZIMIRA, STANISLAW AU - OSZCZAPOWICZ, JANUSZ TI - Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties DP - 2005 May 01 TA - Anticancer Research PG - 2043--2048 VI - 25 IP - 3B 4099 - http://ar.iiarjournals.org/content/25/3B/2043.short 4100 - http://ar.iiarjournals.org/content/25/3B/2043.full SO - Anticancer Res2005 May 01; 25 AB - In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin, as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these analogs were significantly lower, with LD50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with a single dose of 75% of the LD50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of the parent drugs. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved